Asbestos breaks and fragments can be the cause mesothelioma Disease

Asbestos breaks and fragments can be the cause mesothelioma Disease

Exposure to hazardous asbestos material can lead to some fatal diseases. When asbestos fibers are broken or fragmented into small pieces they are inhaled or swallowed and attack the body. An interesting study is called, "Genetic effects of crocidolite in Chinese hamster lung cells" of SL Huang, D. Saggioro, H. Michel husband and HV Malling-Mutation Research / Fundamental and Molecular Mechanisms of Mutagenesis Volume 57, Issue 2, 1978, pp. 225 - 232 Here is an excerpt:... "Abstract - Chinese hamster lung cells in the presence of crocidolite displayed inhibition of cell growth cultured Cell death was connected directly observed with the phagocytosis of larger fibers by means of trypan blue Watersoluble components crocidolite did not appear to inhibit cell growth chromosome aberrations were of the asbestos induced breaks and fragments

 -... Aberrations electron microscopic preparation were mainly restricted to structural aberrations shown that asbestos was present in slightly phagosomes phagocytosed asbestos seemed to be a weak mutagen in its ability to induce gene mutation in the hypoxanthine-guanine phosphoribosyl transferase locus " "Mortality of a cohort exposed to chrysotile asbestos" Another interesting study is called, by Weiss, William MD -. Journal of Occupational and Environmental Medicine: November 1977 - Volume 19 - Issue 11 Here is an excerpt: "Abstract - A 30-year historical cohort mortality study was made ​​of 264 men during 1935-1945, who worked in a chrysotile asbestos products factory for a year or more and lived January 1, 1945 made ​​follow-up was 94. % completed. The total standardized mortality rate (SMR) is only 0.61, while the SMR for all cancers was 0.75, 0.93 for lung cancer and gastrointestinal cancer 1.05. Two men died from asbestosis.

All SMR was higher for men who had worked the same age after adjustment for five years or longer than for men who worked one to four years, but the 30-year mortality. asbestos-related diseases for the differences in labor duration had no influence on mortality. The data show a positive experience exposed mortality for men, single chrysotile. "Another interesting study is called," Asbestos bodies in bronchoalveolar lavage reflect lung asbestos body concentration "of P De Vuyst, P Dumortier, Moulin E, N Yourassowsky, Roomans P, P de Francquen and JC Yernault - Eur Respir J 1988; 1:362-367. Here is an excerpt: "Asbestos body (AB) on two counts of bronchoalveolar lavage (BAL) fluids and digested lung tissue samples were engaged in one hundred consecutive subjects who performed a thoracotomy procedure, especially for lung carcinoma

A good correlation (r = 0.73). When was restrictive selection criteria take into account how the analyzed lung lavage homolaterally, performed by the same trained physician were made ​​found between the two sets of values ​​for the entire group of subjects., this correlation improved (r = 0.82). absence of AB or AB counts low (less than 1 AB / ml) in BAL was approximately 70% of cases to a concentration of less than 1,000 AB / gm and in 100% of cases to concentrations of less than 10,000 AB / gm in patients with BAL with more than 1 AB / ml contained the lung tissue of 85% over 1000 AB / gm and the fabric of 44% contain more than 10,000 AB / gm over 10 AB / ml BAL, contain all the lung tissue more than 10,000 AB / gm . since lung tissue is not readily available in patient assessment of their asbestos BAL analysis seems a useful tool to evaluate lung AB concentrations .. This technique can not be performed, but are, in patients with severe impairment of the lung, which does not allow sufficient recovery of BAL fluid "If you found any of these excerpts interesting, please visit the article in its entirety