A group that has been deeply affected by asbestos are iron workers. They actually have one of the highest rates of mesothelioma of any business group and the use of asbestos was so ubiquitous during your workday.Exposure resulted in a variety of ways. Workers may inhale asbestos paint sprayed on steel beams. Might also inhaling asbestos dust during sanding or drilling. Even some of their clothing was made of asbestos materials.If ever going to find a cure for mesothelioma or lung cancer, will have to fully fund medical research and raise public awareness.
One interesting study is called, "Asbestos, chromosomal deletions and alterations of tumor suppressor genes in human malignant mesothelioma" by S. Siva Murthy, and Joseph R. Testa - Molecular Oncology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania. Funded by: National Cancer Institute grant number CA-45745, CA-06927 - State of Pennsylvania. Here's an excerpt:. "Summary - Exposure to carcinogenic asbestos is considered as an important factor contributing to the development of most malignant mesotheliomas (MMS) to emphasize the role of asbestos in MM and summarize the genetic and molecular findings cytogenetic this pathology. accumulation numerous clonal chromosomal deletions more MMs suggests a multistep process of tumorigenesis, which is characterized by loss and / or inactivation of tumor suppressor genes multiple (TSG).
Cytogenetics and loss of heterozygosity ( LOH) analysis of MM have shown frequent deletions of specific sites within chromosome arms 1p, 3p, 6q, 9p, 13q, 15q and 22q. Moreover, ETG within two of these regions, ie in p16/CDKN2A-p14ARF NF2 9p21 and 22q12, is frequently altered in MMS. homozygous deletion seems to be the main mechanism affecting p16/CDKN2A-p14ARF, whereas inactivating mutations with allelic loss occur in NF2 locus. Finally, Recent studies have demonstrated the presence and expression of the simian 40 (SV40) virus in many MMS. SV40 large T antigen has been shown to inactivate the Rb and p53 TSG products, suggesting the possibility that the asbestos and SV40 could act as cocarcinogens MM. the frequent occurrence p16/CDKN2A-p14ARF and homozygous deletions of SV40 Tag capacity to bind TSG products suggest that disruption of both pathways Rb-and p53-dependent growth regulatory are critically involved in the pathogenesis of MM. J. Cell. Physiol. 180:150-157, 1999. © 1999 Wiley-Liss, Inc. "Another interesting study is called," Asbestos induces selective release of lysosomal enzymes from mononuclear phagocytes "of Philip Davies Anthony C. Allison, Jill Ackerman, Ann Butterfield and Susan Williams. - Division of Cell Pathology, MRC Clinical Research Centre, Watford Road, Harrow, Middlesex HA1 3UJ, UK. Here's an excerpt:. "Association of inhaling asbestos and lung disease has been recognized for many years.1 Asbestosis is a chronic inflammatory reaction in the terminal bronchioles and alveoli of the lung with considerable fibrosis leading to distortion and eventual destruction of the alveoli.'s also an association between asbestosis and bronchogenic cancer2 development and Wagner et al .. 3 have noted the appearance of diffuse pleural and peritoneal mesothelioma in individuals exposed to asbestos dust and in laboratory animals after intrapleural injection of asbestos "If you find any of these excerpts helpful, please read the entire
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