DNA studies revealed a new source of cancer-promoting

DNA studies revealed a new source of cancer-promoting

Some British and U.S. researchers on Thursday ( 3/10 ) , say they have identified a new source of cancer triggers in the region of the genome that is not widely researched and previously regarded as " junk " .

Researchers from the University of Yale , the Wellcome Trust Sanger Institute and other institutions , the project unites data from two large-scale genome analysis - known as the 1000 Genomes Project and the ENCODE project - to study the DNA of non- code and its relationship with disease risk .

Unlike genomic region coded , where 23,000 genes code for proteins are , without - code area , which consists of 98 percent of the human genome , is not widely understood .

The team found some areas with no - code DNA showed a low level of variation is almost the same , and calling it the " ultra - sensitive " .

In the area of ​​ultra - sensitive , they examined a specific marker of DNA which, when altered , lead to the biggest disruption in many genes , giving rise to the disease , according to Xinhua - Reuters monitored on Friday afternoon .

They combine all the information to develop a computer system called FunSeq , which prioritize genetic variants in the region without a code - based prediction of their impact on human disease .

Teams that apply FunSeq to 90 cancer genomes including breast cancer , prostate cancer and brain tumors , and found nearly 100 drive - code without potentially lead to cancer .

Among the new findings is that the changes in DNA markers that seem to have a very large impact on the development of breast cancer . The marker changes occur in the ultra - sensitive region that is so central to many network -related genes , the researchers said .

" Our technique allows scientists to focus on the most important part of the function in the region of the genome with no - code , " said Professor Mark Gerstein , senior author of the University of Yale , in a statement . " This is not only beneficial for cancer research , but also can be developed for other genetic diseases . "

The findings are published in the U.S. journal , Science .
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