Asbestos Carcinogenicity Is Well Established And Can Lead To Mesothelioma

Asbestos Carcinogenicity Is Well Established And Can Lead To Mesothelioma

Asbestos exposure a stimulus for the development of the disease is, the carcinogenic effect of the mesothelium and lung tissue is well documented. An interesting study is called researching this problem, "Silica, asbestos, man-made mineral fibers, and cancer" by Kyle Steenland and Leslie Stayner - Cancer Causes and Control - Volume 8, Number 3 / May, 1997. Here is an excerpt: "Abstract - Around three million workers in the United States are estimated to be exposed to silica, mineral fibers, asbestos and man-made The lung is the primary target organ of concern Each of these substances is composed mainly of silicon and oxygen,.. asbestos and silica are crystalline and asbestos, and man-made mineral fibers are fibers. Artificial mineral fibers, and asbestos are used as an insulating agent, the former being usually replaces the latter in the past years. silica is used in foundries, ceramics and brick-making, and is miners encountered.

A meta-analysis of 16 of the largest studies with well-documented Siliziumdioxidexposition and low probability of confounding factors by other occupational exposures, showing a relative risk (RR) of 1.3 (95 percent confidence interval [CI] = 1.2 to 1 , 4). lung cancer risks are highest and most consistent for silicotics that the highest doses (RR = 2.3, CI = 2.2-2.4 have to get over 19studies). The data for mineral fibers continue to the International Association for Research on Cancer judgment of 1988 that mineral fibers, a possible human carcinogen (Group 2B) should be supported. Recent epidemiological studies provide little evidence for carcinogenicity lung for either glass wool or rock / slag wool. ceramic fiber, a much less exposure than glass wool and rock / slag wool, are of concern, because of the positive animal tests, but there are not enough human data. Regarding asbestos is the carcinogenic effect for the lung and mesothelium well established.

Regarding the controversy over chrysotile and mesothelioma, the data chrysotile does suggest cause mesothelioma, although it may be less . potent than amphibole asbestos "Another interesting study is called," Increased risk of malignant mesothelioma of the pleura after residential or domestic exposure to asbestos: a case-control study in Casale Monferrato, Italy "by C. Magnani, P Dalmasso, A Biggeri , C Ivaldi, D Mirabelli, and B Terracini - Environ Health Perspect .. September 2001, 109 (9): 915-919. Here is an excerpt: "Abstract - The association of malignant mesothelioma (MM) and non-occupational asbestos is currently under discussion Our study examines environmental and domestic exposure to asbestos in the city where the largest Italian asbestos cement was (AC) factory This population-based case.. -control study included pleural MM (histologically) incidents in the area in 1987-1993, matched by age and sex to two controls (four if younger than 60). diagnoses were confirmed by a panel of five pathologists.

We surveyed 102 cases and 273 controls in the years 1993-1995, of 116 and 330 eligible subjects. The information has been checked and completed on the basis of factory and city office files., we adjusted analyzes for occupational exposure in the AC industry. In The town had no other relevant industrial sources of exposure to asbestos. Twenty-three cases and 20 controls lived with an AC worker [odds ratio (OR) = 4.5, 95% confidence interval (CI) 1.8 to 11:1)] ., the risk was higher for the offspring of AC workers (OR = 7.4, 95% CI, 1.9 to 28.1). Topics attending high school in Casale also showed an increased risk (OR = 3.3, 95 % CI 1.4 to 7:7), with spatial trend with increasing distance from the AC factory;:. lives in Casale was with a very high risk (95% CI, 6.2 to 68.6 OR = 20, after selection of AC workers) assigned 6. The present study confirms the association of environmental asbestos and pleural MM, controlling for other sources of exposure to asbestos, and suggests that environmental factors cause a greater risk than domestic exposure. "A third study is called, ". Radiological findings as predictors of mortality in Quebec asbestos workers" by FD Liddell, JC McDonald - Br J Ind Med 1980; 37:257-267 - Here is an excerpt: "Abstract - Two cohorts of chrysotile miners and Müller in Quebec were selected to study the extent to which breast made ​​X-rays, while still employed predict mortality. article presents especially insights into the much larger cohort of 4559 men (two-thirds past workers) whose last radiograph was with by an experienced six readers into what the UICC / Cincinnati (U / C) Classification evaluated was located, by the end of 1975, there were 1,543 deaths in this age group.

 Results were usually confirmed in the other cohort, 988 current male workers who had in 1967-8 was of questionnaires examined for respiratory symptoms and smoking and by lung function tests, and for all six readers had 1966 in the radiographs assessed U / C classification; 130 men had until the end of the year died in 1975. men with an X-ray abnormality, heavy dust, or a history of smoking had relative risks (RR) of total mortality greater than one.'s death from pneumoconiosis was with small parenchymal opacities, usually irregular, of profusion l / l or more are connected, and with heavy dust exposure, but not smoking. Most of those who had died of lung cancer cigarettes smoked, or were heavily exposed to dust or both. Small parenchymal opacities were in most, but not all over deaths due to lung cancer . deaths from other malignancies showed no uniform dust or x-ray pattern.

RRs of deaths from most other causes have been collected for specific radiological features. mistake in predicting mortality was primarily due to deaths in which was Asbestos Disease not the primary cause, but may be a factor. The main results validated the U / C classification convincingly, especially since the films had been taken as a routine and were of modest quality. spite of objective rules for reading and the fact that all six readers were to develop the classification contributes, there bound to be some observer variability. Importance of recording technology and the need for careful control of reading is obvious., our results support the use of chest radiograph for surveillance of asbestos workers and for environmental monitoring. However, its protective effect for the individual worker is to the extent that radiological progression remains limited after withdrawal from exposure and the carcinogenic risk with dust already retained interests. "When you have found any of these excerpts, please read them in their entirety. We all owe a debt of gratitude to these researchers