Asbestos Mesothelioma and environmental protection in the workplace

Asbestos Mesothelioma and environmental protection in the workplace

Asbestos has to be always taken as one of the deadliest industrial materials in use. This revelation was a major impetus for environmental inspections in the workplace. An interesting study is called researching this issue, "The relationship between respiratory disorders and asbestos pleural abnormality in an active work force." By Bourbeau J, Ernst P, J Chrome, Armstrong B, Becklake MR. - Am Rev Respir Dis. October 1990, 142 (4) :837-42nd Here is an excerpt: "Abstract - be seen with the general improvement of the environmental controls on holdings in which asbestos is used, a growing number of workers who show pleural plaques isolated The question is whether this is associated with respiratory disorders independent of parenchymal disease. unresolved., the question was re-examined by quantitative not recognizable gallium-67 lung scanning to consider early parenchymal change on the chest radiograph.

We conducted a cross-sectional study of 110 construction insulators currently all at work. Overall, had 58.2% pleural anomaly, 52.5% pleural plaques only, and 5.5% is diffuse pleural thickening as from the PA chest radiograph assessed. Compared to those without such a pleural abnormality had a decline in FEV1 and FVC on average of 222 and 402 ml (p less than 0.05), and those with isolated pleural plaques, a decrease in the average of 200 and 350 ml (p less than 0.05), after taking into account age, height, smoking, and the presence of parenchymal abnormality by X-ray Thoracic and gallium uptake assessed. The complaint of dyspnea with strenuous activities also became clear to the width and circumference of the chest wall pleural thickening (p less than 0.05), independent of parenchymal disease. This study suggests that the most common radiological findings in asbestos-exposed, isolated pleural plaques with a significant reduction of FEV1 and FVC, which can not be attributed to the presence of X-ray and subradiographic pulmonary fibrosis are associated. "is called An interesting article," Increased epidermal growth factor receptor protein in a human mesothelial cells in response to long asbestos fibers "by JC Pache, YM Janssen, ES Walsh, TR Quinlan, CL Zanella, RB Low, DJ Taatjes and BT Mossman -. Am J Pathol. 1998 Feb., 152 (2): 333-340. Here is an excerpt: "Epidermal Growth Factor (EGF) is a potent mitogen for human mesothelial cells and autophosphorylation of the EGF receptor (EGF-R) occurs in these cell types after exposure to asbestos, a carcinogen with the development of mesothelioma

 Here was the. intensity and distribution of EGF-R protein by immunocytochemistry in a human cell line mesothelial (MET5A) exposed to various concentrations of crocidolite asbestos, and man-made vitreous fibers (MMVF 10) documented. while cells in contact with or phagocytic shorter fibers (or = 60 microM) showed intense staining for EGF R.In contrast, the A549 human lung carcinoma cells neither elongation nor showed increased accumulation of EGF-R protein in response to the long fibers. patterns of aggregation, and increases in the EGF-R protein in mesothelial cells phagocytic long asbestos fibers were being watched by diffuse staining of phosphotyrosine residues in asbestos-exposed cultures., these studies show that the aggregation of EGF-R by long fibers cell signaling cascades important in asbestos-induced carcinogenesis mitogenesis and initiate "A third interesting study called, "Asbestos Bodies in Human Lungs at Autopsy" by Dzidra Cauna, MD,. Robert S. Totten, MD, Paul Gross, MD - JAMA. 1965, 192 (5) :371-373rd Here is an excerpt: "Abstract - The incidence of asbestos bodies in the lung was studied in 100 autopsies of adults averaging smears were made ​​from the cut surfaces of the upper and lower lobes of both lungs

The slides were dried and stored, without coloring, and round.. 400 low-power fields were examined in each slide. routine histological sections of expanded lungs were also examined in all cases. asbestos bodies were found in 41% of subjects. they were not encountered in persons up to the age of 24 years. Among males the incidence was 47% and in women 34%. Though significant microscopic pulmonary fibrosis was found in two positive cases, no case of classical asbestosis was found. mesothelioma of the pleura was not encountered. primary lung carcinoma occurred in a patient with asbestos bodies and in a without. "When you found any of these excerpts interesting, please read the studies in their entirety. We all owe a great debt to these researchers for their important work