Cancer Incidence Among Workers Due To Exposure To Asbestos Dust And Fibers

 Cancer Incidence Among Workers Due To Exposure To Asbestos Dust And Fibers

Some professions are considered dangerous when it comes to asbestos exposure. For example, affects people working as pipefitters, plumbers, electricians and from an overly of mesothelioma disease. This was the subject of a great deal of research. An interesting study is called, "Asbestos exposure, smoking habits and the incidence of cancers among production and maintenance workers in an electrochemical plant" by Bjorn Hilt, MD, Sverre Langad, MD, MSc, Aage Andersen Jan Rosenberg, MD - Department of Occupational Medicine, Telemark Sentralsjukehus, Porsgrunn, Norway, Cancer Registry of Norway, Montebello, Oslo, Norway, Department of Health, Norsk Hydro, Porsgrunn Fabrikker, Porsgrunn, Norway - American Journal of Industrial Medicine - Volume 8 Issue 6, pages 565-577. Here is an excerpt:. "Abstract - The incidence of cancer was in a cohort of 287 men who were exposed to asbestos in a nitric acid production plant in 1928, studied during the observation period from 1953 to 1980 all cancer cases among cohort members were in the cancer registry identified. For the whole cohort, 42 cases of cancer were observed versus 30.6 expected.

Figures for cancer of the lung and pleura combined The corresponding figures for a were heavily exposed subcohort 11, 17 were observed compared to 3.7 expected. observed and 1.2 expected. In this group there was also an increased incidence of colon cancer with 3 cases against 0.8 expected cases observed. within the entire cohort, four cases of pleural and one case of peritoneal malignant mesothelioma have been found. There were also An increased incidence of malignant melanoma of the skin observed with expected 3 cases against 0.6. cases, which were registered as cancer of unknown origin, there were 7 cases observed and 1.4 expected. There was no increased rate ratio for cancer at any point before 20 years after the first exposure to asbestos., the smoking habits of all cohort members were received and the relative rates of lung cancer were calculated in relation to smoking habits. Together with previous studies, the results show a multiplicative model for the interaction between asbestos exposure and smoking in relation to . risk of lung cancer "Another interesting study is called," Tests for the effects of asbestos on benzo (a) pyrene carcinogenesis in the respiratory tract "by Miller, L., Smith, WE, Berlin, SW Release Date 1965 Jan 01 - Ann. NY Acad. . Sci, (USA); Journal Volume: 132 Here is an excerpt: "Hamster 25 intratracheal injections of 0.5 mg benzopyrene (BaP) were placed in Tween-60, with or without 0.25 mg chrysotile (Chrys) Asbestos 173-214 days after the injections, 4 tumors. animals were found in 3/5 surviving animals subjected to BaP alone during 7/7 (15 total) in the given BaP plus Chrys found. Three of them were larger than 3 mm. added Chrys or Tween alone or control animals had no tumors.

16 injections of 0.5 mg BaP in Tween-60 with or without 2.5 mg of amosite (AM) asbestos were given hamster. 29% of the group given BaP and 26% of the group given BaP plus AM had tracheobronchial tumors when at Day 240 sacrificed a form of asbestos synergistically increased carcinogenic activity of BaP .. Environmental and Molecular Mutagenesis Volume 33 Issue 2, Pages 153 -. yield of tumors with time after stopping the injections suggesting reversible effect reduced "Another interesting study is called , "DNA single-strand breaks by asbestos fibers in human pleural mesothelial cells in vitro" induced - 160 Here is an excerpt: "Abstract - The mechanisms of cellular effects and DNA damage caused by asbestos fibers in human mesothelial cells are not well understood We exposed transformed human pleural mesothelial cells to 1-4 g/cm2 crocidolite and 10-100 ng /. ml tumor necrosis factor alpha for up to 48 hours and studied the induction of DNA damage with the comet assay. As a positive control, 100 were M H2O2., the DNA single-strand breaks were as mean tail moments and as distributions of the tail DNA determined in the cell. Comet assay showed significant but reversible increases in median tail moments, but not exposed in the distribution of comet tails in the histograms in cells 1 g/cm2 crocidolite for 6 hours.

 At higher concentrations of asbestos fibers in all indices the comet assay showed a significant and irreversible change. All doses of TNF-induced marginal increase in the mean tail moments. Mean tail moments were highest in cells with simultaneous treatment TNF-and crocidolite. In the cells pretreated with inhibitors of antioxidant enzymes (aminotriazole for catalase and buthionine sulfoximine for-glutamylcysteine ​​synthetase) asbestos fibers slightly increased oxidant related fluorescence of dichlorofluorescein (DCFH), but did not cause further increases in median tail moments. This study shows that asbestos fibers DNA single-strand breaks cause in human mesothelial cells. since the Causes If you found inhibition of antioxidant enzymes does not have an effect on the DNA damage caused by the fibers, mechanisms other than free radicals in the induction of DNA damage to be involved by mineral fibers. "any of these excerpts interesting, please read the studies in their entirety