Fat consumption influences the risk for tumor recurrence
Saturated fatty acids increase the risk of a PSA rise again after radical prostatectomy, so for a relapse (recurrence) of prostate cancer, the result of a new American study.Fats are for many organisms, including humans because of their high calorific value of the most important energy storage. Each molecule consists of fatty glycerol, a trihydric alcohol, which is connected to three, which may be very different fatty acids. Their saturation (with hydrogen) determines its value for the diet:
Only plants can make certain unsaturated fatty acids needed by the human as a source of indispensable components of every cell. They are therefore considered to be essential, as a vital nutritional components such as vitamins. Animal foods contain predominantly saturated fatty acids and unsaturated little.
Unsaturated fatty acids that are healthier than saturated, is generally known. So are fat (especially animal, saturated fatty acids), and obesity as risk factors for the development of prostate cancer (see Causes ). Obesity also increases the risk of a PSA rise again after radical prostatectomy and percutaneous radiotherapy for localized prostate cancer (on these treatments, see radical prostatectomy and radiation therapy ).
One possible explanation for this is the change in overweight hormone metabolism. Since obesity with an increased intake of energy and this is accompanied by fat, but the effect could also go back to saturated fatty acids. This opportunity went researchers from Houston (Texas, USA) in a recent study by:
Participants in the study were 390 men who had undergone because of localized prostate cancer radical prostatectomy. They were asked about their eating habits in the year before diagnosis, divided into two groups with different levels of consumption of saturated fat and a BMI (Body Mass Index) from 30kg/qm classified as overweight (strong). In addition, we detected many more data about other risk factors (eg the tumor according to the histologic finding) and the physical activities.
Results
Compared to the group with low and moderate amount of saturated fatty acids in the diet (group N) (Group H) were the average age slightly lower as well (as expected) the BMI and the intake of calories and fat slightly higher in the group with a high proportion . Otherwise, the groups were comparable. A clear correlation between the amount of saturated fatty acids and other factors not was not found, even with physical activity or body weight.
Five years after surgery were 80% of the N group "PSA-free" (including 85% of normal weight and 70% of obese people), but only 65% of the H group. Overall, the PSA level increased during follow-up in 20% of men again. In the H group this occurred significantly more often and earlier than in the N group: on average almost twice as often and after 27 versus 45 months.Obese men of the H group had the shortest "PSA-free" survival time (19 months), normal weight of the H-group (29 months) how overweight the N group (42 months), medium-sized and normal-weight of the N group the longest ( 46 months).
Conclusion of the authors
The risk of PSA rise again after radical prostatectomy for localized prostate cancer increases with a high content of saturated fatty acids in the diet before diagnosis: It occurs almost twice as often and for a considerably earlier than at a low percentage. And regardless of any possible excess weight, which has been shown as a separate, weaker risk factor.
As the effect of the saturated fatty acids is concluded, settled with this study do not explain (eg impact on sex hormones and insulin, concomitant administration of other, occurring in the same food substances). Also for further tests are needed. Then you'd better understand the relationship between the disease and modifiable factors such as diet and obesity and could develop methods to decrease in patients with prostate cancer by a lower intake of saturated fat, the risk of progression of the disease and to patients with a high risk to recognize and treat targeted.
Notes: In another study, no influence of BMI was on the "PSA-free" survival (see Radical prostatectomy in obese men with prostate cancer ). Because in overweight PSA levels are lower than in normal weight that they have a relapse could be detected somewhat later, occurs more often even earlier, when it was found in this study (see Subsequent cancer diagnosis in overweight? ).
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