The scientists, whose study is published in 'Nature'-established four categories of breast tumors based on mutations found in the samples analyzed: luminal A and B (which have positive hormone receptors and are considered less aggressive), HER2 positive, and triple negative or basal (so called because they lack receptors for estrogen, progesterone and HER2 protein on their surface).
By identifying the most frequent mutations of these four categories the researchers found that the most aggressive tumors, basal, which often affect young women and constitute 10% of all breast tumors share genetic characteristics with ovarian cancer, with which are more common than any of the other subtypes of breast cancer.
Genetic analysis showed that basal tumors is very common that the TP53 gene, which also tends to occur in ovarian cancer is found mutated. As this type of breast tumors do not always respond well to chemotherapy, the sharing features with this neoplasm could help scientists in their search for new effective therapeutic strategies based on the drugs used in the treatment of ovarian cancer , although this is only a possibility on which research is needed.
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