Increase multivitamins prostate cancer risk?
It is possible that taking multivitamins protect against the development of prostate cancer, but accelerated its growth, the most important result of a new, large American study.
For this study, data from more than 295,000 men were evaluated, who had participated in the so-called NIH-AARP Diet and Health Study. Within five years, prostate cancer was diagnosed in 10,241 men, 8,765 of them in a locally limited and in 1476 an advanced tumor. Within six years, 176 men had died of prostate cancer.
Of the participants had more than 48% never occupied about 47% up to 7 times per week, and almost 5% more than 7 times per week multivitamin supplements. With the vitamin intake at the same time increased the signs of a healthier lifestyle and the frequency of prostate cancer screening, but also taking other supplements (dietary supplements, here most vitamin C, vitamin E and calcium).
The analysis showed no overall association between multivitamin intake and a localized prostate cancer. With a supply of more than 7 times per week, but the risk of advanced disease by almost a third were increased and the mortality from prostate cancer nearly twice as high.Were men with early prostate cancer omitted under the assumption that they are turning to supplements, the effect disappeared in advanced tumors, the mortality rate increased, however.
Were the high multivitamin consumption taken in addition (more than 7 times per week) or selenium, folic acid or vitamin E, the risk of advanced disease and mortality further measures (eg selenium almost 6-fold mortality). However, it also increased the risk of a localized tumor up to 37% (with vitamin E with increasing dose). The fact that these substances may increase the incidence of prostate cancer is also known from other studies (for vitamin E conflicting results, at least in smokers), according to the authors. However, the increase could also be due to the existence of certain (eg, health-conscious) both go subgroups of men frequent cancer screening as well as more take supplements.
At high multivitamin use additional beta carotene and an increased intake of tomato products could increase the risk of advanced tumors, and additional zinc increased the mortality rate to just over four times. Other supplements (eg, vitamins A and C, calcium, iron) and dietary habits and other factors showed no significant effect. While in other studies an increase in prostate cancer risk is assessed differently by beta carotene, this is demonstrated for zinc in an investigation. Perhaps, however, are for contaminants (eg cadmium) of the zinc preparation charge.
In comparison with a negative family history positive (cases of prostate cancer in relatives) at high multivitamin consumption, the risk for a locally advanced tumor at two and half times and mortality from prostate cancer increased to over 16 times. This could be also explained by the fact that men are taking with positive family history because of their increased risk of prostate cancer preventive supplements.
Loosely translated, is the conclusion of authors: We have proved that multivitamins do not reduce the risk of prostate cancer. An excessive consumption or a similar behavior even increased the risk of advanced disease and mortality it. Because multivitamin supplements consist of a combination of several vitamins and men more revenue with a high multivitamin use a variety of additional supplements, we were able to identify or quantify not responsible for the observed correlations special ingredients. Our finding of a significantly increased risk of prostate cancer in men who are taking multivitamin supplements is important and needs to be investigated further.
Notes: In this study, missing some information, for example on the composition of multivitamin preparations, the duration of intake and effects on other diseases. It shows once again that studies of diet and nutritional supplements very difficult (also hard to interpret and expensive) are. In the light of possible interests of supplement manufacturers makes the number of positive studies clairaudient. However, this study reinforces the still-growing data available that supplements are not always healthy and their intake has to be weighed in each case. In addition, the realization that micronutrients such as vitamins and trace elements in feed in the form of natural products and supplements can have a different effect and that, so far as they prevent any disease, do not have to automatically promote their healing matures. In this sense, some supplements to support the treatment of prostate cancer are to be viewed critically.
Source
Lawson, KA, Wright ME, Subar A., T. Mouw, A. Hollenbeck, A. Schatzkin, MF Leitz man: Multivitamin use and risk of prostate cancer in the National Institutes of Health - AARP Diet and health study. JNCI 10 (2007) 754-764
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