Malignant process may also affect the lymph nodes on the other side of the chest cavity and beyond.
In Stage IV cancer spreads to distant organs or tissues.
Recurrence of malignant mesothelioma
Recurrence of malignant mesothelioma - is the re-emergence of the disease after treatment. Malignant neoplasm may reappear in the pleural cavity, or in a new location.
Therapies
There are different methods of treating patients with a diagnosis of malignant mesothelioma. For the treatment of malignant mesothelioma, there are various methods of therapy. Some treatments are standard (treatment that exists today), some - are explored in clinical trials. Clinical trials are conducted to improve existing therapies or to obtain data on the effectiveness of new approaches. When clinical trials show that is better than the treatment they may become the new standard treatment. Many patients can discuss with your physician participation in clinical trials. In some tests continues to enroll patients not yet treated.
There are three types of standard therapy:
Surgical method
In the treatment of malignant mesothelioma of the following types of surgeries:
Wide local excision: Surgical removal of the tumor and its surrounding healthy tissue.
Plevroektomiya and decortication: Surgery to remove part covering the lungs and the inner surface of the chest tissue, as well as part of the outer surface of the lungs.
Ekstraplevoralnaya pneumonectomy: Surgery to remove the entire lung and part of the layer of tissue lining the chest, the diaphragm and the inner surface of the heart bags.
Plevrodezis: A surgical procedure based on the use of chemicals or drugs that contribute to the formation of adhesions between the pleural sheets. First, liquid is drained from the pleural cavity using a special catheter or tube is introduced into the cavity of chemotherapy drug or other medicament. Adhesions prevent further accumulation of fluid in the pleural cavity.
Even if the doctor removes the tumor, which he sees during surgery, some patients spend postoperative chemotherapy and radiation therapy for the complete destruction of the remaining tumor cells. Conducted after surgery is called adjuvant treatment.
Radiation therapy
Radiation therapy - a method of treating esophageal cancer in a high-frequency X rays or other radiation. The method allows to achieve complete destruction of cancer cells or slow tumor growth. There are two kinds of radiation therapy. With external radiotherapy beams from the unit, located close to the patient are directed at the tumor. Internal radiation therapy, radioactive substances are gaining in needles, tubes or catheters that are induced in the tissue around the tumor or in the tumor. The choice of method depends on the radiation therapy type and stage of the cancer process.
Chemotherapy
Chemotherapy - is a method of treating cancer with cytotoxic drugs that target the destruction of tumor cells or malignant growth slowdown. When receiving chemotherapy inside, intravenous or intramuscular administration of drug enters the bloodstream, destroying circulating tumor cells throughout the body (systemic chemotherapy). If chemotherapy administered directly into the spinal canal, into the affected organ or any body cavity, such as in the abdominal, it is called regional chemotherapy.
With combination chemotherapy used several anticancer drugs. The method of administration of chemotherapy depends on the type and stage of the malignant process.
In clinical studies, the search for new treatments. Information about these studies can be found at NCI (National Cancer Institute, USA) or your physician with whom you can discuss participation in such studies.
Localized Malignant Mesothelioma (Stage I)
With the localization of malignant mesothelioma in only one area, surgery is performed to remove the tumor and its surrounding healthy tissue.
With the localization of malignant mesothelioma in more than one area can be the following treatment:
Plevroektomiya and decortication with or without radiation therapy as palliative therapy to reduce symptoms and improve quality of life.
Extrapleural Plevroektomiya.
Radiation therapy as palliative therapy to reduce symptoms and improve quality of life.
Participation in clinical trials of anticancer drugs, which are injected directly into the chest cavity after surgical removal of the tumor.
Participation in clinical trials of combinations of surgical treatment, radiation therapy and chemotherapy.
Participation in clinical trials of new treatments.
Common mesothelioma (stage II, stage III, stage IV)
The methods of treatment common malignant mesothelioma include:
Surgical intervention to drain the liquid collected in the chest cavity, and reduce the symptoms caused by this. To prevent further accumulation of fluid in the pleural cavity can be performed plevrodezis.
Plevroektomiya and decortication as palliative therapy to reduce symptoms and improve quality of life.
Participation in clinical trials of combination therapy.
Participation in clinical trials of combinations of surgical treatment, radiation therapy and chemotherapy.
Participation in clinical studies of anticancer drugs, which are administered directly into the thoracic cavity or abdominal cavity in order to reduce tumor size and stopping its growth.
Recurrence of malignant mesothelioma
Recurrence of malignant mesothelioma can be treated by the following methods:
Clinical studies of biological therapy.
Clinical studies of chemotherapy.
Clinical studies of surgical treatment.
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