DNA Study Reveals New Source Trigger Cancer

DNA Study Reveals New Source Trigger Cancer

 Some researchers England and the United States ( U.S. ) , Thursday ( 3/10 ) , say they have identified a new source of cancer triggers . The source was located in the region of the genome that is not widely researched and previously regarded as " junk " .

Researchers from the University of Yale , the Wellcome Trust Sanger Institute and other institutions , the project unites data from two large-scale genome analysis , known as the 1000 Genomes Project and the ENCODE project . Step was to study the DNA of non- code and its relationship with disease risk .

Unlike genomic region coded , where 23,000 genes code for proteins are , without - code area , which consists of 98 percent of the human genome , is not widely understood . The team found some areas with no - code DNA showed a low level of variation is almost the same , and calling the area ' ultra - sensitive ' .

In the area of ​​ultra - sensitive , they examined a specific marker of DNA , which when altered , lead to the biggest disruption in many genes . As a result , according to the Xinhua report quoted on Friday ( 4/10 ) , is able to cause disease .

They combine all the information to develop a computer system called FunSeq , which prioritize genetic variants in the region without a code - based prediction of their impact on human disease . Teams that apply FunSeq to 90 cancer genomes including breast cancer , prostate cancer and brain tumors , and found nearly 100 drive - code without potentially lead to cancer .

Among the new findings is that the changes in DNA markers that seem to have a very large impact on the development of breast cancer . The marker changes occur in the ultra - sensitive tissue at the center for many gene -related , the researchers said .

" Our technique allows scientists to focus on the most important part of the function in the region of the genome with no - code , " said Professor Mark Gerstein , senior author of the University of Yale , in a statement . " This is not only beneficial for cancer research , but also can be developed for other genetic diseases . " The findings are published in the U.S. journal , Science .